张嘉昕，医学博士，讲师。2021年毕业于西北大学中药生物工程专业，获医学博士学位；2021年9月至2024年12月于西北大学生物学流动站从事师资博士后研究；2025年9月至今任西安医学院基础与转化医学研究所讲师。
主要从事活性成分受体蛋白筛选、配受体间相互作用机制、中药药理学新方法以及寡核苷酸荧光探针开发应用研究。通过PDPL筛选中药活性成分潜在体内受体蛋白，并基于特异性结合及其介导的生理作用进行验证，同时从热力学及结构变化角度解析配受体间具体结合机制。
围绕活性成分潜在体内受体蛋白筛选方法及其结合机制，构建中药组方配伍机制阐释的新方法。同时基于寡核苷酸Hairpin结构、Chair-type G-quadruplex结构及K(I)诱导的Parallel G-quadruplex结构，设计含特定碱基序列的OND探针，联合猝灭基团对荧光素的猝灭作用及PGQ对荧光配体的荧光增强作用，建立用于特定重金属离子及生物活性分子高选择性、高灵敏检测的方法，并研究其相关机制。
[1] Zhang J*, Wang Z, et al. Identification of the ZU5 domain in UNC5C as a potential receptor for Schisandrin A: experimental and computational insights. Bioorganic Chemistry. 2026;173:109666.
[2] Zhang J, Wang Z, Wang J, Zhang R, Dong X, Bian L*. Investigation of binding mechanism for human plasminogen Kringle 5 with its potential receptor vWA1 domain in Cochlin by bio-specific technologies and molecular dynamic simulation. Bioorganic Chemistry. 2022;127:105989.
[3] Zhang J, Ma X, Chen W, Bai Y, Xue P, Chen K, Chen W, Bian L*. Bifunctional single-labelled oligonucleotide probe for detection of trace Ag(I) and Pb(II) based on cytosine-Ag(I)-cytosine mismatches and G-quadruplex. Analytica Chimica Acta. 2021;1151:338258.
[4] Zhang J, Zhang L, Zhou Y, Li K, Dai X, Bian L*. An efficient fluorescence reversible regulation strategy with single labelled oligonucleotide HEX-OND successively triggered by Hg(II) and Cysteine: The application and mechanism. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2023;299:122817.
[5] Zhang J, Zhang L, Zhou Y, Li K, Dai X, Bian L*. The fluorescence regulation of a tri-functional oligonucleotide probe HEX-OND in detecting Pb(II), cysteine, and K(I) based on two G-quadruplex forms. Analytical and Bioanalytical Chemistry. 2023;415(14):2763-2774.
[6] Zhang J, Yang W, Li S, Bian L*. Fluorescent reversible regulation of cysteamine-capped ZnSe quantum dots successively induced by photoinduced electron transfer of herring sperm DNA and intercalation binding of ethidium bromide. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2021;249:119116.
[7] Zhang J, Wang K, Xue P, Chen X, Bian L*. Molecular recognition and interaction between human plasminogen Kringle 5 and voltage-dependent anion channel-1 by biological specificity technologies and molecular dynamic simulation. Biophysical Chemistry. 2022;280:106710.
[8] Zhang J, Bai J, Duan M, Yang J, Bian L*. Derivation of adsorption capacity and adsorption isotherm by a single adsorbate concentration in liquid-solid system. Chemical Papers. 2021;75(6):2459-2476.
[9] Zhang J, Zhang R, Liu W, Chen H, Bian L*. Distribution and transition of stable conformations in unfolding of bovine insulin induced by urea and guanidine hydrochloride. Chinese Journal of Analytical Chemistry. 2020;48(9):e20114-e20125.
[10] 张嘉昕，张椰莉，宋思慧，边六交*. 纤溶酶原Kringle 5与层粘连蛋白α3链G1结构域间的结合及其对血管内皮细胞增殖凋亡的影响。中华实验外科杂志。2022，39(11)：2113-2116。
