主要从事血管和免疫靶向药物发现及作用机制、核酸功能分子和药物递送体系等研究。主持陕西省自然科学基础研究计划青年项目1项、西安医学院校级科研基金项目1项,参与国家自然科学基金面上项目等课题2项。共发表学术论文9篇,其中以第一作者发表SCI论文4篇。
(1)陕西省科技厅自然科学基础研究计划青年项目,2025JC-YBQN-1086,基于靶标释放策略的PirB-NgR1核酸适配体纳米自组装体系在脑缺血神经损伤修复中的应用研究,2025/01-2026/12,5万元,在研,主持。
[1] Duan M, Sun Q, Duan J, Chen Z, Yang C, Zhai C, Cao M, Liu H, Wei M, Chen Y, Lei L, Gou X, Bian L*, Luan J*. Screening and identification of Kringle 5-inhibitory microRNAs from Astragali radix decoction pieces using immobilized magnetic beads. International Journal of Biological Macromolecules. 2026;369:152757.
[2] Duan M, Li K, Zhang L, Zhou Y, Bian L*, Wang C*. Screening, characterization and specific binding mechanism of aptamers against human plasminogen Kringle 5. Bioorganic Chemistry. 2023;137:106579.
[3] Duan M, Bai J, Yang J, Qiao P, Bian L*. Molecular recognition and binding of CcrA from Bacteroides fragilis with cefotaxime and ceftazidime by fluorescence spectra and molecular docking. Journal of Biological Inorganic Chemistry. 2022;27(3):283-295.
[4] Duan M, Bai J, Yang J, Shi P, Bian L*. Screening and identification of bioactive components resistant to metallo-beta-lactamase from Schisandra chinensis (Turcz.) Baill. by metalloenzyme-immobilized affinity chromatography. Journal of Chromatography B. 2021;1165:122524.
[5] 段美娇,周雅琪,王翠玲,边六交*. 核酸适配体对纤溶酶原Kringle 5抗血管生成功能的影响。中国现代应用药学。2023,40(21):2909-2916。